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Sweating Matters Blog
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21 June 24
The Three Causes of Hyperhidrosis
As with most things related to the human body, things are always more complicated than they appear. And so goes the cause, or more accurately, causes of hyperhidrosis. A recent review study* points to multiple causes behind the excessive sweating condition. When 'googling' the cause of hyperhidrosis, an 'overactive' nervous stimulation of sweat glands is often cited as the cause of the condition. While this is true, two other causes need to be included as sources of excessive sweating.
Overexpression of Aquaporin Proteins: Researchers have identified specific genes that lead to the overproduction of aquaporin proteins. These proteins reside within sweat glands and facilitate the movement of water into sweat gland ducts, thereby increasing sweat production.
Increased Acetylcholine Receptors: Another significant but often overlooked cause is the heightened number of acetylcholine receptors on nerve cell surfaces. Acetylcholine is a neurotransmitter essential for transmitting signals between nerve cells. An increased number of receptors amplifies nerve cell sensitivity, intensifying signals that stimulate glands to produce sweat more intensely.
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These multiple causes underscore the complexity of hyperhidrosis and highlight diverse pathways that can be targeted for therapeutic interventions. Recognizing these factors is crucial for advancing research and developing effective treatments for focal hyperhidrosis.
*Clin Auton Res. 2017 Dec;27(6):379-383
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3 July 2024
Hyperhidrosis and skin infections. Is there a Link?
Are individuals with excessive sweating more predisposed to skin infections? While it is suspected that this might be the case, an increased prevalence of skin infections in HH has not conclusively been shown. However, a Danish study* of over 400 diagnosed hyperhidrosis individuals demonstrated....
Helping Create Dryer Lifestyles
9 July 2024
Demystifying the Chemistry of Hyperhidrosis Treatments
Many people may feel hesitant about using certain treatments for hyperhidrosis simply because of their names. Words like aluminum, acid, or toxin can sound intimidating, especially to those without a background in chemistry. Let's break down three common active ingredients in hyperhidrosis treatments to understand them better....
12 July 24
Hyperhidrosis Treatments: Snake Oils and Placebos
A placebo is a substance that elicits a positive effect due to the individual's perception of its benefit, rather than any active ingredient. This isn't necessarily bad, as long as the treatment seems to work, right?
Well, when it comes to treating hyperhidrosis, placebo effects are rare or non-existent.....
16 July 24
Debunking Common Hyperhidrosis Myths
As such, there remains a large proportion of people who do not fact-check the information they consume. So we decided to straighten out the score on a number of misperceptions about hyperhidrosis. While there are many, we will focus on just a few here, with more to be covered in a future blog post....
The principle function of sweating is to rid the body of dangerous toxins
Sweating actually plays a minor role in terms of processing toxins - the kidneys and liver are the primary organ systems responsible for doing so. Sweating is a mechanism involved in regulating body temperature.....
20 Aug 2024
Sofpironium - a new topical gel for hyperhidrosis
Another option in the treatment of focal primary hyperhidrosis is coming soon. Sofpironium or Sofdra (brand name) was recently approved......
