Hyperhidrosis and Human Skin

The skin is the largest organ of the body. And not all parts of the average adult's 3000 square inches of this organ are created equally. Different areas vary in terms of color, thickness, and hair density. Some parts can feel smooth, while others may be slightly rough. Certain areas are characterized by wrinkles, dryness, or oiliness, and sensitivity to touch, sensation, or pain can also differ. Moreover, some regions of the skin may react more strongly to topical allergens or irritants than others.

Certain regions of the body are predisposed to excessive sweating, notably the underarms, face, scalp, palms, and soles. This heightened sweat production is due to these areas containing a higher concentration of sweat glands compared to others. For instance, regions like the palms and soles are depicted in the accompanying figure, showing a notably higher average number of sweat glands per square centimeter.

Hyperhidrosis and Optimizing its Treatment

Hyperhidrosis treatment should be optimized by tailoring it to the specific sensitivities and sweating severities of different skin regions. For instance, the approach to treating palms should differ from that used for underarms. Underarm skin is notably more sensitive and prone to irritation, so treatment should start conservatively.

Initially, a lower strength topical gel like DryDerm 10 or 15% is recommended for underarms. If the desired results are not achieved and no irritation occurs, the strength can be increased, up to a maximum of 20%.

Conversely, palms and soles can typically tolerate higher concentrations due to their lower sensitivity. Treatment can begin with a strength of 20% and may be escalated to 45%, depending on the individual's response and tolerance. Throughout treatment, it's crucial to monitor both the therapeutic benefits and any potential skin irritation as the strength of the treatment is adjusted. This tailored approach ensures effective management of hyperhidrosis while minimizing adverse effects.

Helping Create Dryer Lifestyles